Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

The foundations of a theory of nonminimal coupling of matter and the gravitational field in the framework of Riemannian (or Riemann-Cartan) geometry are presented. In the absence of matter, the Einstein vacuum field equations hold. In order to allow for a Newtonian limit, the theory contains a new parameter l0 of dimension length. For systems with finite total mass, l0 is set equal to the Schwarzschild radius.

In describing the flawless regularity of developmental processes and the correlation between changes at certain genetic loci and changes in morphology, biologists frequently employ two metaphors: that genes ‘control’ development, and that genomes embody ‘programs’ for development. Although these metaphors have an admirable sharpness and punch, they lead, when taken literally, to highly distorted pictures of developmental processes. A more balanced, and useful, view of the role of genes in development is that they act as suppliers of the material needs (...) of development and, in some instances, as context‐dependent catalysts of cellular changes, rather than as ‘controllers’ of developmental progress and direction. The consequences of adopting this alternative view of development are discussed. (shrink)

A new challenge for Bible translators A few decades ago the development of the dynamic-equivalent method of translation (which later became known as functional equivalence) broke radically away from the formal and traditional method of translation. Since then the functional-equivalent approach has undergone refinement, but the development can no longer be called revolutionary. However, research in the art of translation has now shifted from the method of translation to the format of the printed text (also called the paralinguistic features of (...) the text). In this article practical examples are given of how the employment of paralinguistic features can underscore the meaning of the text of the Bible, especially the Afrikaans Bible since it has become imperative to start working on a new translation. (shrink)

Mark, G. La crisis de la física clásica por obra del experimento.--Thirring, J. La transformación del sistema conceptual de la física.--Hahn, J. La crisis de la intuición.--Nöbeling, J. La cuarta dimensión y el espacio curvo.--Menger, C. La nueva lógica.

Burgess, J.P. and Rosen, G. Subject with No ObjectElliott, R.Faking Nature.